• br Funding M I is supported

  2022-01-05

  

  Funding M.I. is supported by European Research Council (ERC) Consolidator Grant 725038, Italian Association for Cancer Research (AIRC) Grant 19891, Italian Ministry of Health (MoH) Grant GR-2011-02347925, Lombardy Foundation for Biomedical Research (FRRB) Grant 2015-0010, the European Molecular B

• Estrus expression after removal of

  2022-01-05

  

  Estrus SB 204070 after removal of P4 insert and before TAI is a clear predictor of greater P/AI in protocols that use GnRH [6,8], EB, or ECP [10,18] as ovulation inducers. Therefore, our third hypothesis was that heifers showing estrus behavior would have greater P/AI, which was supported in both tr

• In vertebrates three cognate receptors or receptor

  2022-01-05

  

  In vertebrates, three cognate receptors or receptor-like sequences have been identified with distinct distributions and functions (Millar, 2005, Neill et al., 2001). Only two types of GnRHR occur in mammals, though (Morgan and Millar, 2004). The mammalian type I GnRHR shares over 80% amino orexin a

• br Acknowledgements This work was

  2022-01-05

  

  Acknowledgements This work was supported by the National Institutes of Health [grant number GM024417]. Introduction In mammals, glucose is the major energy substrate supporting conceptus development after SC-9 australia formation [1,2]. While the equine morula uses similar amounts of pyruvat

• Olanzapine has been reported to attenuate insulin secretion

  2022-01-05

  

  Olanzapine has been reported to attenuate insulin secretion, cause insulin resistance (Chintoh et al., 2008) and reduce whole body carbohydrate oxidation (Klingerman et al., 2014). However, a blunting of these effects in Gcgr−/− mice would not appear to explain the protection against olanzapine-indu

• TGX-221 CaCl was from the Radiochemical Centre

  2022-01-05

  

  45CaCl2 was from the Radiochemical Centre (Amersham, UK), NaVO3 was from Reachim (Moscow, Russia). Tetrodotoxin was purchased from Calbiochem, DTNB from Merck, Darmstadt, Germany. Nifedipine was synthesized in the Institute of Drug Research, Modra, Slovakia and was kindly provided by Dr. Zdeno Mahrl

• wnt inhibitor Inflammatory pain is very common in the clinic

  2022-01-05

  

  Inflammatory pain is very common in the clinic. A study demonstrated that galanin was upregulated after nerve injury or inflammation (Ma and Bisby, 1997). It has been reported that galanin plays an important role in the transmission of nociceptive information in the spinal cord of rats with inflamma

• The activation of GPR FFA

  2022-01-05

  

  The activation of GPR40/FFA1 signaling triggers the PLC/PIP2 signaling pathway and results in Ca2+ release from the endoplasmic reticulum (ER). Increased Ca2+ levels may lead to activation of different protein kinases, such as Ca2+/calmodulin-dependent protein kinase type IV, Akt, extracellular sign

• To discriminate the peripheral and central involvement of FA

  2022-01-05

  

  To discriminate the peripheral and central involvement of FAAH in paracetamol action, we proposed a pharmacological strategy challenging the analgesic action of paracetamol observed in an inflammatory context with either a peripherally-restricted FAAH inhibitor (URB937, Clapper et al., 2010, Moreno-

• The root of Danshen has been widely used as

  2022-01-05

  

  The root of (Danshen) has been widely used as traditional Chinese medicine for many years and shown to exhibit significant pharmacological activities for a variety of human diseases including cancers. Tanshinones, the major active components, belong to a group of an abietane-type diterpenes contain

• PR-619 Histone demethylases are involved in the transcriptio

  2022-01-05

  

  Histone demethylases are involved in the transcriptional output of the AR and hypoxia signaling pathways, and thus contribute to prostate cancer development [12]. For example, the histone demethylase KDM3A serves as a transcriptional coactivator of HIF1α and AR in regulation of their target genes [1

• Traditional methods for HATs activity assays mainly

  2022-01-05

  

  Traditional methods for HATs activity assays mainly depend on radioisotope labelling of histone substrates, which is limited by the complex procedures, hazards and wastes of radioactive materials. Hence, various alternative approaches such as electrochemical analysis, fluorescence and colorimetric a

• Toxoplasma gondii is an exceptionally tractable apicomplexan

  2022-01-04

  

  Toxoplasma gondii is an exceptionally tractable apicomplexan parasite that expresses a limited yet representative subset of apicomplexan cyclase orthologs, making it an ideal model for investigating cyclic nucleotide signaling in Apicomplexa. Of the five putative nucleotide cyclases, only TgACα1 and

• br Introduction Depressive disorder is a syndrome characteri

  2022-01-04

  

  Introduction Depressive disorder is a syndrome characterized by a group of heterogeneous symptoms that affect more than 350 million people worldwide, 4% of world population (WHO, 2012). The WHO estimates depression will be the leading global cause of disability in 2020, with tremendous economic c

• br Acknowledgments br Introduction Myelin one of the fundame

  2022-01-04

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the experienced of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cells (SC) in

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