• In terms of cytotoxicity studies under two dimensional

  2021-11-09

  

  In terms of cytotoxicity studies under two-dimensional cell culture conditions, only two of the above-mentioned publications with liposomal formulations of tyrosine kinase inhibitors reported viability data as compared to respective free drugs. On the one hand, liposomal gefitinib exerted strongly r

• ARRY-380 receptor Consistent with our result Camacho Barquer

  2021-11-09

  

  Consistent with our result, Camacho-Barquero and coworkers showed that curcumin reduced phospho-P38 MAPK. P-38 MAPK is a key effector of several downstream factors that eventually modulate the homing of monocytic cells during the onset of intestine inflammation (Camacho-Barquero et al., 2007). Along

• Compounds that induce exocytosis in cultured cells include C

  2021-11-09

  

  Compounds that induce exocytosis in cultured abk include Ca2+-dependent [14] or Ca2+-independent [15] mechanisms. Ca2+-dependent exocytosis releases soluble enzyme content from lysosomes [16] operating by increasing the cytosolic concentration of Ca2+[13] by recruiting extracellular Ca2+[14], libera

• br STAR Methods br Acknowledgments We

  2021-11-09

  

  STAR★Methods Acknowledgments We thank the TCGA PanCanAtlas Analysis Working Group. This study was supported in part by grants from the NIH (CA175486 and CA209851 to H.L., CA217842 to G.B.M., and CCSG grant CA016672); a grant from the Cancer Prevention and Research Institute of Texas (RP140462

• The following are the supplementary data related to this

  2021-11-08

  

  The following are the supplementary data related to this article. Introduction Target therapies have achieved significant gains in the fight against cancer, however, they are still a long way from providing generally curative treatments for the majority of cancers. Targeted agents can be used wi

• The translation of the HCV genomic

  2021-11-08

  

  The translation of the HCV genomic RNA is initiated in a different manner, referred to as internal initiation: the 40S subunit directly forms a binary complex with the HCV genomic RNA via an internal RNA sequence called IRES, which is located in the 5′-UTR (Pestova et al., 1998, Tsukiyama-Kohara et 

• Recent studies on detailed biochemical and structural

  2021-11-08

  

  Recent studies on detailed biochemical and structural characterization of plant GSNOR following website confirmed their similarities to mammalian homologues [16], [17], [18], [19]. Compared to human GSNOR, plant GSNORs exhibit differences in the composition of the anion-binding pocket, which negativ

• br GSNOR activity and functions

  2021-11-08

  

  GSNOR activity and functions The identification of the enzyme responsible for GSNO decomposition dates back to 1998, when Jensen and colleagues described an NAD(P)H-dependent GSNO catabolizing activity in cytosolic fractions obtained from rat liver [16]. Upon purification, they identified this en

• br Materials and Methods br Results All of the

  2021-11-08

  

  Materials and Methods Results All of the studied transporter genes were expressed at detectable levels in all the analyzed samples at mRNA level by means of applied rt-PCR method (CTChlorpropamide was observed for ABCC4, ABCC1, ABCG2, SLC22A3, and SLC22A18 (less than 10% of mean expression fo

• Transient forebrain ischemia in rodents induces a reduction

  2021-11-08

  

  Transient forebrain ischemia in rodents induces a reduction in expression of mRNA encoding the AMPA receptor subunit GluR265, 66, 67, 68, 69 (Fig. 3). gluR2 mRNA expression is markedly reduced in the CA1 region (the TAI-1 receptor region most vulnerable to ischemia-induced damage), but not in the C

• Nevertheless in the brain we found that

  2021-11-08

  

  Nevertheless, in the brain, we found that trehalose phosphorylates AMPK, which is a metabolic sensor. AMPK is known to be transiently activated in muscle by acute exercise [21,22]. Bayod et al. also reported that AMPK was significantly activated in both the cerebral cortex and hippocampus in exercis

• In general fish has a limited

  2021-11-08

  

  In general, fish has a limited ability for digestion and metabolism of carbohydrate though carbohydrate is the cheapest dietary energy and carbon source to animals and the best candidate for replacing dietary protein (Enes et al., 2009, Kamalam et al., 2017, Wilson, 1994). Furthermore, the analysis

• br Conflict of interest br

  2021-11-08

  

  Conflict of interest Acknowledgements Introduction Second generation antipsychotic drugs (SGAs) such as olanzapine are widely used in treating individuals with schizophrenia and bi-polar disorder and are increasingly prescribed for other conditions such as anxiety (Pringsheim and Gardner, 2

• Next we investigated the transfer of peptides and

  2021-11-08

  

  Next, we investigated the transfer of peptides and proteins between contacting cells by nano-LC-MS/MS analysis using the fractions corresponding to molecules higher than 3 kDa. The MS data analysis revealed the direct transfer of several labelled peptides between receivers and donors. Labelled pepti

• Second although HO expression in the stromal macrophages has

  2021-11-08

  

  Second, although HO-1 expression in the stromal macrophages has been seen in the other cancer tissues [21], the impact of HO-1 expression on EAOC progression has not been explored. We have found that the CD163+ M2-like bepridil were HO-1+ in OE, but malignant transformation may be associated with,

16039 records 546/1070 page Previous Next First page 上5页 546547548549550 下5页 Last page