• A major question which arises from the aforementioned

  2018-11-07

  

  A major question which arises from the aforementioned work is if activation of a DDR within telomere repeats indicates physical DNA double stranded breaks or is merely changes in chromatin without an associated lesion. Recently, a new method has been developed which allows the accurate detection of

• Importantly the interconnections between SAMD SASP and cell

  2018-11-07

  

  Importantly, the interconnections between SAMD, SASP and cell senescence do not form a simple linear cause-effect relationship. There is ample evidence for the existence of multiple positive feedback loops between the major components of the senescent phenotype (Fig. 3). Positive feedback loops betw

• Las facultades fiscales del Congreso de la Uni

  2018-11-07

  

  Las facultades fiscales del Congreso de la Unión (Cámara de Diputados y de Senadores) fueron minuciosamente reglamentadas. Así, el Congreso tenía la facultad “para imponer las contribuciones necesarias dihydrofolate reductase inhibitor antibacterial cubrir el presupuesto” (art. 73, fracción VII), ba

• GPCR Compound Library br Identification of candidate DRPs us

  2018-11-07

  

  Identification of candidate DRPs using mass spectrometry The candidate DRPs were excised from preparative CBB-stained gels and subjected to the nano-LC–MS/MS analysis. Out of 125 leaf and 112 root protein spots analyzed, 73 and 40 protein species were identified, respectively, representing 49 uni

• br Value of the data br Data experimental design

  2018-11-07

  

  Value of the data Data, experimental design, materials and methods Sample preparation method In this investigation, concrete samples were fabricated using ordinary Portland cement, variable amounts fine and coarse aggregate and water (Table 1). Initially, required amount of cement was mixed

• The depleted RNA was fragmented using RNase III

  2018-11-07

  

  The depleted RNA was fragmented using RNase III in preparation for amplification of the cDNA library, which was produced by reverse transcription from adapters attached to the ends of the RNA molecules, in accordance with the SOLiD™ Total RNA-Seq kit protocol (Life Technologies™, CA). Next, 6% denat

• br Experimental design materials and methods br Conflicts of

  2018-11-07

  

  Experimental design, materials and methods Conflicts of interest Acknowledgments This study was founded by grants from CNPq (Conselho Nacional do Desenvolvimento Científico e Tecnológico - process 302885/2011-0) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). Mirian

• The authors also suggest that there is an interviewer gender

  2018-11-07

  

  The authors also suggest that there is an interviewer gender effect in key violence indicators. That is the case when using FTFI and asking about whose prevalence is lower than that among men interviewed by men. Regarding FTFI method and in agreement with previous studies (Davis et al., 2010), it

• nvp-aew541 Notably a recent training study asked years

  2018-11-07

  

  Notably, a recent training study asked 6 years old preschoolers to learn grapheme to phoneme correspondence. Although these children had already acquired some letter knowledge (10 upper case letters and 5.8 lower case letters) prior to training, they did not possess neural tuning for words associate

• The current results are consistent with the animal

  2018-11-07

  

  The current results are consistent with the animal models of cannabinoid exposure during adolescence (Rubino et al., 2008; Schramm-Sapyta et al., 2007) and suggest that more human research is needed on the long-term effects of cannabis use in adolescence. In consideration of the animal studies and t

• Activation of the amygdala was also reduced in heavy marijua

  2018-11-07

  

  Activation of the amygdala was also reduced in heavy marijuana users compared to controls—an effect observed for both negative and positive words. Along with the insula, the amygdala is part of a network involved in translating interoceptive responses to emotional stimuli into emotional experience (

• Methods br Results br Discussion This study assessed changes

  2018-11-07

  

  Methods Results Discussion This study assessed changes in axonal fiber organization over a 2-year period of continued heavy cannabis use in young adults who initiated use during adolescence. White matter microstructure is known to show continued developmental changes during this age period (L

• br What are the basic attention mechanisms behind attentiona

  2018-11-07

  

  What are the basic attention mechanisms behind attentional bias? Attention is not a single construct, but rather constitutes a series of mechanisms and processes that are both distinct and interrelated (Raz and Buhle, 2006). That is, while sub-components of attention are thought to play specializ

• When animal size and previous agonistic

  2018-11-07

  

  When animal size and previous agonistic experience are equivalent, social stratification emerges from small individual differences in several factors, including aggression, stress reactivity, social behavior, and “home-field advantage”, or benefits for residents versus intruders (Barnett, 1958; Sapo

• br Conclusions br Acknowledgements br Introduction

  2018-11-07

  

  Conclusions Acknowledgements Introduction Over the past few years the neural architecture of how cognitive control is supported when having to process emotional information has slowly begun to be uncovered (e.g., Cromheeke and Mueller, 2014; Dolcos and McCarthy, 2006; Kanske and Kotz, 2011;

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