• Sildenafil Citrate: Proteoform-Driven Mechanisms in Vascu...

  2025-09-22

  Explore how Sildenafil Citrate, a selective cGMP-specific phosphodiesterase type 5 inhibitor, advances the study of proteoform interactions, apoptosis regulation via cGMP signaling, and vascular smooth muscle relaxation. This article details mechanistic insights and new research directions using Sildenafil Citrate in cardiovascular and cell signaling studies.

• Filipin III in Quantitative Cholesterol Mapping of Hepati...

  2025-09-19

  Explore the pivotal role of Filipin III, a cholesterol-binding fluorescent antibiotic, in quantitative membrane cholesterol visualization—highlighting its applications in liver disease research and its unique strengths for freeze-fracture electron microscopy and lipid raft analysis.

• X-press Tag Peptide: Enhancing Precision in Protein Purif...

  2025-09-18

  Explore the scientific utility of X-press Tag Peptide as a robust N-terminal leader peptide for protein purification in recombinant protein expression. This article delves into its structural features, solubility properties, and unique role in facilitating affinity purification using ProBond resin and Anti-Xpress antibody detection.

• Studies on both TCDD treated mice

  2025-03-03

  

  Studies on both TCDD treated mice and AhR null mice have also pointed to a role of AhR in hematopoiesis [65], [66]. Singh et al. showed that AhR is a negative regulator of HSC (hematopoietic stem cell) proliferation, while deletion of AhR leads to spleen enlargement in juvenile and adult mice [67].

• The putative physiological meaning of epinephrine related

  2025-03-03

  

  The putative physiological meaning of epinephrine-related hepatic drug transporter regulation remains to be established. It is nevertheless noteworthy that the catecholamine rather decreases expression of sinusoidal SLC transporters like NTCP, OAT2, OAT7, OCT1, OATP1B1 and OATP2B1 whereas those of c

• APN accounts for of total plasma

  2025-03-03

  

  APN accounts for 0.01% of total plasma proteins in humans; this proportion increases with age to a small extent (Barb et al., 2007). Normal APN levels in the circulation range 3–30μg/mL (Aprahamian and Sam, 2011). APN levels are lower in men than women due to the presence of testosterone and even mo

• Adiponectin belongs to the CTRP C

  2025-03-03

  

  Adiponectin belongs to the CTRP (C1q/TNF-related protein) superfamily. Except for adiponectin, 15 additional members have been identified (CTRP1-15) (Schaffler and Buechler, 2012). Of all the CTRPs, CTRP9 has the highest identity to adiponectin in globular domain (Wong et al., 2009). The structure o

• In fact serotonin is a major

  2025-03-03

  

  In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc

• Epithelial mesenchymal transition EMT is the process

  2025-03-03

  

  Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical Transcription factor modulator cytoskeleton, lose their junctions and apical-basal polarity, change cell sh

• In model plant Arabidopsis there are

  2025-03-03

  

  In model plant Arabidopsis, there are 13 myosin XI isoforms (XI-1, XI-2, XI-A, XI-B, XI-C, XI-D, XI-E, XI-F, XI-G, XI-H, XI-I, XI-J, and XI-K) and 4 myosin VIII isoforms (ATM1, ATM2, VIII-A, VIII-B) [9,13]. Arabidopsis myosin XIs have the common domain composition: a motor domain that interacts with

• Several studies have recently used

  2025-03-03

  

  Several studies have recently used optogenetics to selectively activate various cholinergic neurons (Jiang et al., 2014). However, most do not explicitly report direct release of GABA from cholinergic fibers, with the exception of our two studies described above (Saunders et al., 2015a, Saunders et 

• The relatively high concentration of

  2025-03-03

  

  The relatively high concentration of 5-HT used in this study (100 µM) is consistent with the concentrations used in other published ex vivo studies (Ropert and Guy, 1991, Passani et al., 1994, Shen and Andrade, 1998). In our paradigm 5-HT was focally applied at the surface of the slice via a fast pe

• Several dehidropregnenolone derivatives functionalized at

  2025-03-03

  

  Several 16-dehidropregnenolone derivatives functionalized at C3, C4, C5 and C6 (Fig. 7) were prepared and evaluated as 5α-reductase inhibitors bearing in mind that after the formation of an enzyme-steroid complex a nucleophilic portion of the enzyme attacks the double bond of the steroid through Mic

• br Results br Discussion Although they do

  2025-03-03

  

  Results Discussion Although they do not have protein-coding capacity, lncRNAs make up a large part of the transcripts of the genome, and they play fundamental roles in carcinogenesis and osteosarcoma progression through regulation of tumor proliferation and metastasis. These lncRNAs include MA

• br Materials and methods Bacterial strains and growth condit

  2025-03-03

  

  Materials and methods Bacterial strains and growth conditions. Escherichia coli TOP10 and E. coli BL21Star (DE3) (ThermoFisher, Waltham, MA) were grown at 37 °C in Luria broth (LB) or LB-agar containing kanamycin (50 μg/ml). Bioinformatic analyses. The amino cas9 mw sequence of Rv2477c was obta

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