• Sulfo-Cy7 NHS Ester: Illuminating In Vivo Mechanisms via ...

  2025-09-26

  Explore how Sulfo-Cy7 NHS Ester, a sulfonated near-infrared fluorescent dye, revolutionizes mechanistic studies of live biological systems. This in-depth article uncovers its unique value in dissecting in vivo disease pathways and addresses the latest scientific advances in fluorescence-based imaging.

• HyperScribe T7 Cy5 RNA Labeling Kit: Empowering Next-Gen ...

  2025-09-25

  Explore how the HyperScribe T7 High Yield Cy5 RNA Labeling Kit revolutionizes fluorescent RNA probe synthesis for advanced gene expression analysis and tumor-selective mRNA delivery. This article uniquely examines the intersection of in vitro transcription RNA labeling, probe optimization, and emerging applications in targeted therapeutics.

• TCEP Hydrochloride: Driving Precision in Modern Capture-a...

  2025-09-24

  Discover how TCEP hydrochloride, a water-soluble reducing agent, revolutionizes sensitivity and precision in advanced capture-and-release analytical assays. Explore its unique chemical versatility and emerging role in next-generation protein modification strategies.

• Streptavidin-FITC in Quantitative Fluorescent Tracking of...

  2025-09-23

  Explore the application of Streptavidin-FITC as a highly sensitive probe for fluorescent detection of biotinylated molecules, especially nucleic acids in intracellular trafficking and nanoparticle delivery studies. This article details new methodological insights, referencing recent advances in LNP research.

• Sildenafil Citrate: Proteoform-Driven Mechanisms in Vascu...

  2025-09-22

  Explore how Sildenafil Citrate, a selective cGMP-specific phosphodiesterase type 5 inhibitor, advances the study of proteoform interactions, apoptosis regulation via cGMP signaling, and vascular smooth muscle relaxation. This article details mechanistic insights and new research directions using Sildenafil Citrate in cardiovascular and cell signaling studies.

• Filipin III in Quantitative Cholesterol Mapping of Hepati...

  2025-09-19

  Explore the pivotal role of Filipin III, a cholesterol-binding fluorescent antibiotic, in quantitative membrane cholesterol visualization—highlighting its applications in liver disease research and its unique strengths for freeze-fracture electron microscopy and lipid raft analysis.

• X-press Tag Peptide: Enhancing Precision in Protein Purif...

  2025-09-18

  Explore the scientific utility of X-press Tag Peptide as a robust N-terminal leader peptide for protein purification in recombinant protein expression. This article delves into its structural features, solubility properties, and unique role in facilitating affinity purification using ProBond resin and Anti-Xpress antibody detection.

• Studies on both TCDD treated mice

  2025-03-03

  

  Studies on both TCDD treated mice and AhR null mice have also pointed to a role of AhR in hematopoiesis [65], [66]. Singh et al. showed that AhR is a negative regulator of HSC (hematopoietic stem cell) proliferation, while deletion of AhR leads to spleen enlargement in juvenile and adult mice [67].

• The putative physiological meaning of epinephrine related

  2025-03-03

  

  The putative physiological meaning of epinephrine-related hepatic drug transporter regulation remains to be established. It is nevertheless noteworthy that the catecholamine rather decreases expression of sinusoidal SLC transporters like NTCP, OAT2, OAT7, OCT1, OATP1B1 and OATP2B1 whereas those of c

• APN accounts for of total plasma

  2025-03-03

  

  APN accounts for 0.01% of total plasma proteins in humans; this proportion increases with age to a small extent (Barb et al., 2007). Normal APN levels in the circulation range 3–30μg/mL (Aprahamian and Sam, 2011). APN levels are lower in men than women due to the presence of testosterone and even mo

• Adiponectin belongs to the CTRP C

  2025-03-03

  

  Adiponectin belongs to the CTRP (C1q/TNF-related protein) superfamily. Except for adiponectin, 15 additional members have been identified (CTRP1-15) (Schaffler and Buechler, 2012). Of all the CTRPs, CTRP9 has the highest identity to adiponectin in globular domain (Wong et al., 2009). The structure o

• In fact serotonin is a major

  2025-03-03

  

  In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc

• Epithelial mesenchymal transition EMT is the process

  2025-03-03

  

  Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical Transcription factor modulator cytoskeleton, lose their junctions and apical-basal polarity, change cell sh

• In model plant Arabidopsis there are

  2025-03-03

  

  In model plant Arabidopsis, there are 13 myosin XI isoforms (XI-1, XI-2, XI-A, XI-B, XI-C, XI-D, XI-E, XI-F, XI-G, XI-H, XI-I, XI-J, and XI-K) and 4 myosin VIII isoforms (ATM1, ATM2, VIII-A, VIII-B) [9,13]. Arabidopsis myosin XIs have the common domain composition: a motor domain that interacts with

• Several studies have recently used

  2025-03-03

  

  Several studies have recently used optogenetics to selectively activate various cholinergic neurons (Jiang et al., 2014). However, most do not explicitly report direct release of GABA from cholinergic fibers, with the exception of our two studies described above (Saunders et al., 2015a, Saunders et 

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