• hESC NPCs and hfNPCs induced different PBMC proliferative re

  2018-11-12

  

  hESC-NPCs and hfNPCs induced different PBMC proliferative responses, despite relatively similar expression levels of HLA, co-stimulatory and adhesion molecules. Multiple other factors that are produced by NPCs and may contribute to the regulation of the immune response such as inducible nitric oxide

• adenosine deaminase Finally we observed decreased leukocyte

  2018-11-12

  

  Finally, we observed decreased leukocyte influx in exosome treated animals. It is likely that the reduced influx is secondary to the reduced cardiac injury after exosome treatment, since leukocyte influx did not differ between the groups at 1h reperfusion. In addition, we found that the reduced infa

• br Conclusion This is the first study to

  2018-11-12

  

  Conclusion This is the first study to derive functional VCMs using the Mlc2v endogenous promoter at a precise chromosal locus. Our mESC line will allow the production of homogeneous and functional VCMs for basic research as well as for cell-based ventricular repair and regeneration. This strategy

• dopamine-2 receptor antagonist br Author contribution The fo

  2018-11-12

  

  Author contribution The following are the supplementary data related to this article. Acknowledgments We thank Catherine Bresse for her valuable assistance in the statistical analysis. This work was supported by the CIRM grant # RL1-00636-1. Introduction The capacity of human embryonic st

• To address the question of whether these HLCs

  2018-11-12

  

  To address the question of whether these HLCs could serve in cellular therapies, a variety of markers of hepatocyte differentiation were considered. For example, production of albumin, a classic marker of hepatocyte differentiation, was observed in HLCs (Fig. 2). However, production of albumin has b

• Our results can be explained

  2018-11-12

  

  Our results can be explained by the following model. During reprogramming, the de novo DNA methyltransferases (DNMTs) methylates not only the promoters of the somatic-specific genes that are undergoing reprogramming, but also the promoters of most cell-specific genes, even if they are not expressed

• To further verify the corneal progenitor state

  2018-11-12

  

  To further verify the corneal progenitor state of R-115777 maturated in CnT-30 medium after induction with SM, we confirmed the protein expression of ABCG2, CK15, and DG-3. These proteins have been previously established as putative progenitor markers of the corneal epithelium (Chen et al., 2004; Da

• br Materials and methods br Results

  2018-11-12

  

  Materials and methods Results Discussion Our comprehensive DNA methylation analysis in many iPS clones has demonstrated that parentally inherited DNA methylation imprint was variably lost at many imprinted regions in iPS norepinephrine reuptake inhibitor (Table 1S). Some imprinted regions

• To assess the involvement of Notch signalling

  2018-11-12

  

  To assess the involvement of Notch signalling on defined cell populations within the AGM microenvironment we established a novel system whereby we co-cultured isolated FLK1+ ap-1 on AGM-derived stromal cell lines. We used inducible expression of either NotchIC or dominant negative MAML as gain- and

• br Conclusions This unique technique

  2018-11-12

  

  Conclusions This unique technique developed in rats allows in less than 15min to biopsy olfactory mucosa, without significant impairment in odor discrimination. We show here that olfactory stem cells can be expanded in vitro. It should however be pointed out that the same technique can be used fo

• Thus the persistent muscle expression

  2018-11-12

  

  Thus, the persistent muscle expression of full length dystrophin remains difficult to achieve currently. Since the discovery of satellite stem interleukin 1 receptor antagonist and the difficulties met in maintaining their differentiation potential during in vitro culture, several promising alterna

• Acknowledgments This work was supported

  2018-11-12

  

  Acknowledgments This work was supported by the Agency for Science, Technology and Research, Singapore. We would like to thank the Cytogenetics laboratory at Singapore General Hospital for karyotyping the iPSC lines and Luqman Hakim for help in characterizing the iPSC lines. We would like to thank T

• LY2228820 The low density lipoprotein receptor related prote

  2018-11-12

  

  The low-density lipoprotein receptor-related protein (LRP) family is an evolutionarily conserved group of cell-surface receptors that regulate diverse biological functions in different organs, tissues, and cell types, in mammals and species of other taxa (Strickland et al., 1994; Croy et al., 2003).

• gpr119 agonist The first initiating event that starts the pr

  2018-11-12

  

  The first initiating event that starts the process of tumorigenesis must originate in a healthy cell. It is possible that this healthy cell may not be a stem cell (O\'Brien et al., 2007). However, given any cell of a healthy self-renewing tissue, the number of divisions that separates this cell from

• br Results br Discussion Pluripotent stem cells offer unprec

  2018-11-09

  

  Results Discussion Pluripotent stem p2x receptors offer unprecedented potential for regenerative medicine as they can be differentiated by a specific sequence of signals to become any cell type of the body. At the same time, any cell product generated from them confers a substantial risk for

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