• For radiochemotherapy it is well

  2020-12-25

  

  For radiochemotherapy, it is well known that mitotic cell death and apoptosis present the major cell death modes. More recently, autophagy-dependent cell death has been described to occur upon radiochemotherapy (Daido et al., 2005, Song et al., 2017). This form of regulated cell death depends on com

• br Acknowledgement This research was supported by

  2020-12-25

  

  Acknowledgement This research was supported by a grant from the National Research Foundation of Korea (NRF-2013R1A1A2011238) funded to Young-Mi Lee. Introduction Stroke is considered a serious disease with high morbidity and high mortality. More than 6 million deaths are reported each year wo

• Two are the sigma receptors identified to

  2020-12-25

  

  Two are the sigma receptors identified to date: the non-opioid receptor, σ1R, and σ2R, whose identity with the Progesterone Receptor Membrane Component 1 (PGRMC-1) protein is in doubt (Chu et al., 2015). Despite endogenous ligands have not been yet identified, drugs of abuse may interact with these

• Among the various neurotransmitter systems pointed out to

  2020-12-24

  

  Among the various neurotransmitter systems pointed out to play a role in the mediation of defensive and antinociceptive responses elicited by environmentally aversive stimuli, the neuropeptide corticotropin-releasing factor or hormone (CRF or CRH) has attracted the interest of many researchers inves

• Stable carbon and nitrogen isotope ratios in bone collagen a

  2020-12-24

  

  Stable carbon and nitrogen isotope ratios in bone collagen and carbon isotope ratios in bone apatite data were obtained by the means of the techniques described in supplementary data (SD1). For collagen, standard indicators have been used to assess its preservation, such as collagen yield, carbon an

• BIX 02565 br Introduction The endeavor to achieve a successf

  2020-12-24

  

  Introduction The endeavor to achieve a successful use of commercial-off-the-shelf (COTS) electronic devices in space is not new and the reasons are well known [1], [2], [3]. More recently, COTS have been widely employed in the manufacturing of low-cost, small satellites, for scientific and even c

• The present study was the first to examine

  2020-12-24

  

  The present study was the first to examine how COMT genotype and estradiol are associated with CL 316243 disodium salt australia functioning in healthy postmenopausal women. We hypothesized that with decreased circulating estradiol after menopause, the COMT genotype relationship to cognition would

• br Collagens as new drivers of

  2020-12-24

  

  Collagens as new drivers of zebrafish tissue regeneration Contrary to mammals, zebrafish possess very high regeneration capacities and thereby represent a versatile model to study tissue and organ regeneration. Adult fish can fully reconstruct their brain, spinal cord, retina, kidney, liver, panc

• Three new trans P Hs

  2020-12-24

  

  Three new trans-P4Hs (AlP4H, MiP4H and ScP4H) discovered by a genome mining approach in this study were all located in branch A containing DaP4H sequence. Although another three candidates from Amycolatopsis mediterranei, Bradyrhizobium sp. ORS285 and O. indicum were successfully expressed as solubl

• br Conclusion and future perspectives LDL cholesterol loweri

  2020-12-24

  

  Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol YC 1 the efficacy of cholesterol lowering, both, with statins and with ezetimibe exhib

• br Acknowledgements This work was supported in part by JSPS

  2020-12-24

  

  Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. Introduction The Cys-loop receptors constitute an important superfamily of ligand-gated ion Digoxin (LGICs) and mediate synaptic transmission in both invertebrate and vertebrate nervous systems (Jones et

• br Membrane receptor Indirect non genomic signaling As

  2020-12-24

  

  Membrane receptor: Indirect non-genomic signaling As mentioned above, not all following website responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could be a

• The authors then showed that Spt

  2020-12-24

  

  The authors then showed that Spt6 interacts directly with the PRC2 subunit Suz12. This interaction occurs in solution but not on chromatin, suggesting that Spt6 may prevent PRC2 recruitment by binding to Suz12. They then mapped the domains in both Spt6 and Suz12 that are involved in this interaction

• Recent studies have reported that miR

  2020-12-24

  

  Recent studies have reported that miR-454 plays an important role in various cellular processes and diseases, such as inflammation, infection, osteogenic differentiation, and cancers [25,27,29,30]. Multiple evidence has documented that miR-454 promotes the proliferation, migration and invasion, and

• The effect of transformation of the

  2020-12-24

  

  The effect of transformation of the linker Y between the carboxylic 7112 synthesis residue and the phenyl moiety of 2b was also investigated, and is illustrated in Table 5. Analogs 2b, 16, and 17, possessing conformationally restricted carboxylic acid residues, tended to show stronger antagonist act

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