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br Tests and measurements We used a set
2020-08-10

Tests and measurements We used a set of FPGA cores for all tests and measurements. Firstly, the control circuit for the Controlled Current Limiter illustrates the proposed TMR method. The circuit contains a D-Register to enable or disable the power to the protected device, a counter, which is use
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br Genomic actions in the
2020-08-10

Genomic actions in the breast Conclusion Clinical studies suggest that progesterone and/or progestins may play a decisive role in the development of breast cancer in women using hormone therapy or oral contraceptives [3], [4]. However, this data are controversial to most experimental investiga
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Another enzyme class that has emerged as
2020-08-10

Another enzyme class that has emerged as a potential alternative to P450s are the so-called ‘unspecific peroxygenases’ (UPOs). They also contain a heme but are extracellularly expressed fungal enzymes that are often more stable than P450 monooxygenases. Importantly, UPOs use H2O2 instead of O2 as th
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234 2 In conclusion we provide convincing evidence that the
2020-08-10

In conclusion, we provide convincing evidence that the PRRSV-induced SGs are indeed bona fide SGs. While we determined that mRNA is present in the PRRSV-induced SGs, we did not distinguish its origin. Future studies will need to determine whether the mRNA stored in PRRSV-induced SGs is of cellular o
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br Results br Discussion CCA is
2020-08-10

Results Discussion CCA is a fatal tumor originating from the intrahepatic bile duct and the prognosis is very poor (Hoyos et al., 2018). CCA is one of the most dangerous primary liver malignant tumors and the most common malignant tumor of the biliary tract worldwide. However, the underlying m
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Methods br Results br Discussion It is well established that
2020-08-10

Methods Results Discussion It is well established that CRSwNP is characterized by TH2 inflammation and eosinophilia.22, 27 Yet it is becoming increasingly apparent that B cells might play an important role in the inflammatory response within the sinus tissue of patients with CRSwNP.8, 9 The l
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As EBI is highly important for generation of an
2020-08-10

As EBI2 is highly important for generation of an efficient T cell-dependent humoral immune response [[5], [6], [7]] it may be that aberrant expression or other dysregulation of this receptor contributes in B cell pathologies. In line with this, EBI2 expression is down-regulated in diffuse large B-ce
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Introduction The carnitine choline acyltransferase family is
2020-08-08

Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) AS-252424 and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of seven
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On the one hand levels of
2020-08-08

On the one hand, levels of up to 20 nM P4 have been reported for a cyprinid species, Labeo rohita, in summer (Suresh et al., 2008). Similarly, P4 concentrations in tilapia, Oreochromis mossambicus, were found to range up to 27 nM (Cornish, 1998). Nevertheless in sturgeon P4 levels of approximately 3
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IL A producing T cells participate in the induction of
2020-08-07

IL-17A producing T cells participate in the induction of EAE [33][34]. IL-17A expression reaches its highest CNS level at disease initiation while it decreases at the peak of disease. On the other hand IFNγ achieves its highest value at the peak of disease [35]. Lymphocytes that produce IL-17A in th
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Mexiletine HCl Similarly another recent study demonstrated t
2020-08-06

Similarly, another recent study demonstrated that oral contraceptives improve endothelial function in young athletes with low Mexiletine HCl and amenorrhea [48]. Further research is needed to investigate whether improvement of endothelial function with hormone therapy translates into a reduction in
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Two primary members of the
2020-08-06

Two primary members of the TRIM family – TRIM5α and TRIM25 – function as antiviral effector and immune regulator, respectively. TRIM5α is one of the best characterized members of the TRIM family (both structurally and functionally) and reported to be an important ubiquitin-mediated regulator of a ma
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To control for MSP amplification bias
2020-08-06

To control for MSP amplification bias, we analyzed PCR products from all DAPK positive sera from OvCa, leiomyoma and IVF patients. We used BstUI LY2801653 of cloned and uncloned MSP products as well as Sanger sequencing of plasmid clones to investigate the methylation state of internal CpG dinucleot
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br Results br Discussion Analysis of
2020-08-05

Results Discussion Analysis of EBI2 expression showed that EBI2 is highly expressed in central memory CD8+ T cells that is in line with previous data from human T cells in which these phosphodiesterase inhibitors express higher levels of EBI2 than naive or effector memory CD8+ T cells (Hanned
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DPP also known as CD is a novel
2020-08-05

DPP-4 (also known as CD26) is a novel therapeutic target for T2DM. DPP-4 is a membrane-bound X-prolyl dipeptidyl peptidase, which involves the degradation of chemokines, such as stromal-cell derived factor 1 (SDF-1) and macrophage derived chemokine, and incretins, such as glucagon-like peptide 1 (GL
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